The vulnerability and resilience of Main Streets in Majority-Minority Communities of NYC, Miami, New Orleans, Atlanta and Memphis are the focus of this COVID-19 Working Group for Public Health and Social Sciences Research. Our research is supported in part by a grant from a National Science Foundation-funded Social Science Extreme Events Research (SSEER) Network housed at the Natural Hazards Center at the University of Colorado Boulder. Additional support comes from universities (schools of planning, policy and public administration) and corporate partners in community and economic development.